Prednisolone rescues Duchenne muscular dystrophy phenotypes in human pluripotent stem cell–derived skeletal muscle in vitro

Duchenne muscular dystrophy (DMD) is a devastating genetic disease leading to degeneration of skeletal muscles and premature death. How dystrophin absence leads to muscle wasting remains unclear. Here, we describe an optimized protocol to differentiate human induced pluripotent stem cells (iPSC) to...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Al Tanoury, Ziad, Zimmerman, John F., Rao, Jyoti, Sieiro, Daniel, McNamara, Harold M., Cherrier, Thomas, Rodríguez-delaRosa, Alejandra, Hick-Colin, Aurore, Bousson, Fanny, Fugier-Schmucker, Charlotte, Marchiano, Fabio, Habermann, Bianca, Chal, Jérome, Nesmith, Alexander P., Gapon, Svetlana, Wagner, Erica, Gupta, Vandana A., Bassel-Duby, Rhonda, Olson, Eric N., Cohen, Adam E., Parker, Kevin Kit, Pourquié, Olivier
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2021
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285911/
https://ncbi.nlm.nih.gov/pubmed/34260377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022960118
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