Prednisolone rescues Duchenne muscular dystrophy phenotypes in human pluripotent stem cell–derived skeletal muscle in vitro

Duchenne muscular dystrophy (DMD) is a devastating genetic disease leading to degeneration of skeletal muscles and premature death. How dystrophin absence leads to muscle wasting remains unclear. Here, we describe an optimized protocol to differentiate human induced pluripotent stem cells (iPSC) to...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Al Tanoury, Ziad, Zimmerman, John F., Rao, Jyoti, Sieiro, Daniel, McNamara, Harold M., Cherrier, Thomas, Rodríguez-delaRosa, Alejandra, Hick-Colin, Aurore, Bousson, Fanny, Fugier-Schmucker, Charlotte, Marchiano, Fabio, Habermann, Bianca, Chal, Jérome, Nesmith, Alexander P., Gapon, Svetlana, Wagner, Erica, Gupta, Vandana A., Bassel-Duby, Rhonda, Olson, Eric N., Cohen, Adam E., Parker, Kevin Kit, Pourquié, Olivier
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285911/
https://ncbi.nlm.nih.gov/pubmed/34260377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022960118
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