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Zinc pyrithione activates the volume-regulated anion channel through an antioxidant-sensitive mechanism

Leucine-rich repeat-containing 8 (LRRC8) volume-regulated anion channels (VRACs) play important physiological roles in diverse cell types and may represent therapeutic targets for various diseases. To date, however, the pharmacological tools for evaluating the druggability of VRACs have been limited...

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Detalles Bibliográficos
Publicado en:Am J Physiol Cell Physiol
Autores principales: Figueroa, Eric E., Denton, Jerod S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2021
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285639/
https://ncbi.nlm.nih.gov/pubmed/33826406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00070.2021
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