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Tumour heterogeneity and evolutionary dynamics in colorectal cancer

Colorectal cancer (CRC) has a global burden of disease. Our current understanding of CRC has progressed from initial discoveries which focused on the stepwise accumulation of key driver mutations, as encapsulated in the Vogelstein model, to one in which marked heterogeneity leads to a complex interp...

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Detalhes bibliográficos
Publicado no:Oncogenesis
Main Authors: Chan, Dedrick Kok Hong, Buczacki, Simon James Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285471/
https://ncbi.nlm.nih.gov/pubmed/34272358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-021-00342-x
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