Prioritizing and characterizing functionally relevant genes across human tissues

Knowledge of genes that are critical to a tissue’s function remains difficult to ascertain and presents a major bottleneck toward a mechanistic understanding of genotype-phenotype links. Here, we present the first machine learning model–FUGUE–combining transcriptional and network features, to predic...

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Udgivet i:PLoS Comput Biol
Main Authors: Somepalli, Gowthami, Sahoo, Sarthak, Singh, Arashdeep, Hannenhalli, Sridhar
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284802/
https://ncbi.nlm.nih.gov/pubmed/34270548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1009194
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