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The effects of intramolecular and intermolecular electrostatic repulsions on the stability and aggregation of NISTmAb revealed by HDX‐MS, DSC, and nanoDSF

The stability and aggregation of NIST monoclonal antibody (NISTmAb) were investigated by hydrogen/deuterium exchange mass spectrometry (HDX‐MS), differential scanning calorimetry (DSC), and nano‐differential scanning fluorimetry (nanoDSF). NISTmAb was prepared in eight formulations at four different...

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Bibliografische gegevens
Gepubliceerd in:Protein Sci
Hoofdauteurs: Hamuro, Yoshitomo, Derebe, Mehabaw Getahun, Venkataramani, Sathya, Nemeth, Jennifer F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley & Sons, Inc. 2021
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284571/
https://ncbi.nlm.nih.gov/pubmed/34060159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.4129
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