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Choice of β-Lactam Resistance Pathway Depends Critically on Initial Antibiotic Concentration
Antibiotic resistance trajectories with different final resistance may critically depend on the first mutation, due to epistatic interactions. Here, we study the effect of mutation bias and the concentration-dependent effects on fitness of two clinically important mutations in TEM-1 β-lactamase in i...
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| Publicado no: | Antimicrob Agents Chemother |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8284463/ https://ncbi.nlm.nih.gov/pubmed/33972257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00471-21 |
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