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Overcoming the Challenges of Pyrazinamide Susceptibility Testing in Clinical Mycobacterium tuberculosis Isolates

Pyrazinamide (PZA) is one of the first-line agents used for the treatment of tuberculosis. However, current phenotypic PZA susceptibility testing in the Bactec MGIT 960 system is unreliable, and false resistance is well documented. Rapid identification of resistance-associated mutations can confirm...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Mok, Simone, Roycroft, Emma, Flanagan, Peter R., Montgomery, Lorraine, Borroni, Emanuele, Rogers, Thomas R., Fitzgibbon, Margaret M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284449/
https://ncbi.nlm.nih.gov/pubmed/33972244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02617-20
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