Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

Neutralizing antibodies (nAbs) elicited against the receptor-binding site (RBS) of the spike protein of wild-type SARS-CoV-2 are generally less effective against recent variants of concern. RBS residues E484, K417 and N501 are mutated in variants first described in South Africa (B.1.351) and Brazil...

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Publicado no:Science
Main Authors: Yuan, Meng, Huang, Deli, Lee, Chang-Chun D., Wu, Nicholas C., Jackson, Abigail M., Zhu, Xueyong, Liu, Hejun, Peng, Linghang, van Gils, Marit J., Sanders, Rogier W., Burton, Dennis R., Reincke, S. Momsen, Prüss, Harald, Kreye, Jakob, Nemazee, David, Ward, Andrew B., Wilson, Ian A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284396/
https://ncbi.nlm.nih.gov/pubmed/34016740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abh1139
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