Molecular characteristics and clinical outcomes of complex ALK rearrangements identified by next-generation sequencing in non-small cell lung cancers

BACKGROUND: Complex kinase rearrangement, a mutational process involving one or two chromosomes with clustered rearrangement breakpoints, interferes with the accurate detection of kinase fusions by DNA-based next-generation sequencing (NGS). We investigated the characteristics of complex ALK rearran...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Xia, Peiyi, Zhang, Lan, Li, Pan, Liu, Enjie, Li, Wencai, Zhang, Jianying, Li, Hui, Su, Xiaoxing, Jiang, Guozhong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8283930/
https://ncbi.nlm.nih.gov/pubmed/34271921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-021-02982-4
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