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Molecular Dynamics Simulations Reveal Interactions of an IgG1 Antibody With Selected Fc Receptors

In a survey of novel interactions between an IgG1 antibody and different Fcγ receptors (FcγR), molecular dynamics simulations were performed of interactions of monoclonal antibody involved complexes with FcγRs. Free energy simulations were also performed of isolated wild-type and substituted Fc regi...

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Bibliografske podrobnosti
izdano v:Front Chem
Main Authors: Kralj, Sebastjan, Hodošček, Milan, Podobnik, Barbara, Kunej, Tanja, Bren, Urban, Janežič, Dušanka, Konc, Janez
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8283507/
https://ncbi.nlm.nih.gov/pubmed/34277572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2021.705931
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