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Loop Grafting between Similar Local Environments for Fc-Silent Antibodies
[Image: see text] Reduction of the affinity of the fragment crystallizable (Fc) region with immune receptors by substitution of one or a few amino acids, known as Fc-silencing, is an established approach to reduce the immune effector functions of monoclonal antibody therapeutics. This approach to Fc...
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| Publicado no: | J Chem Inf Model |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2020
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7686954/ https://ncbi.nlm.nih.gov/pubmed/32379970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.9b01198 |
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