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Downregulation of FeSOD-A expression in Leishmania infantum alters trivalent antimony and miltefosine susceptibility

BACKGROUND: Superoxide dismutase (SOD), a central component of the antioxidant defence system of most organisms, removes excess superoxide anions by converting them to oxygen and hydrogen peroxide. As iron (Fe) SOD is absent in the human host, this enzyme is a promising molecular target for drug dev...

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Detalhes bibliográficos
Publicado no:Parasit Vectors
Main Authors: Santi, Ana Maria Murta, Silva, Paula Alves, Santos, Isabella Fernandes Martins, Murta, Silvane Maria Fonseca
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8281622/
https://ncbi.nlm.nih.gov/pubmed/34266485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13071-021-04838-8
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