Structure-based modeling and dynamics of MurM, a Streptococcus pneumoniae penicillin resistance determinant present at the cytoplasmic membrane

Branched Lipid II, required for the formation of indirectly crosslinked peptidoglycan, is generated by MurM, a protein essential for high-level penicillin resistance in the human pathogen Streptococcus pneumoniae. We have solved the X-ray crystal structure of Staphylococcus aureus FemX, an isofuncti...

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Publicado en:Structure
Main Authors: York, Anna, Lloyd, Adrian.J., del Genio, Charo I., Shearer, Jonathan, Hinxman, Karen.J., Fritz, Konstantin, Fulop, Vilmos, Dowson, Christopher.G., Khalid, Syma, Roper, David.I.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8280954/
https://ncbi.nlm.nih.gov/pubmed/33740396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2021.03.001
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