Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization

Common fragile sites (CFSs) are specific breakage-prone genomic regions and are present frequently in cancer cells. The (E2-independent) E3 ubiquitin-conjugating enzyme FATS (fragile site-associated tumor suppressor) has antitumor activity in cancer cells, but the function of FATS in immune cells is...

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Publicado no:Nat Commun
Main Authors: Zhang, Lijuan, Zhang, Kai, Zhang, Jieyou, Zhu, Jinrong, Xi, Qing, Wang, Huafeng, Zhang, Zimu, Cheng, Yingnan, Yang, Guangze, Liu, Hongkun, Guo, Xiangdong, Zhou, Dongmei, Xue, Zhenyi, Li, Yan, Zhang, Qi, Da, Yurong, Liu, Li, Yin, Zhinan, Yao, Zhi, Zhang, Rongxin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8280123/
https://ncbi.nlm.nih.gov/pubmed/34262035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24610-x
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