A novel methylated analogue of L-Mimosine exerts its therapeutic potency through ROS production and ceramide-induced apoptosis in malignant melanoma

Melanoma is an aggressive and highly metastatic type of skin cancer where the design of new therapies is of utmost importance for the clinical management of the disease. Thus, we have aimed to investigate the mode of action by which a novel methylated analogue of L-Mimosine (e.g., L-SK-4) exerts its...

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Publicat a:Invest New Drugs
Autors principals: Kyriakou, Sotiris, Cheung, William, Mantso, Theodora, Mitsiogianni, Melina, Anestopoulos, Ioannis, Veuger, Stephany, Trafalis, Dimitris T., Franco, Rodrigo, Pappa, Aglaia, Tetard, David, Panayiotidis, Mihalis I.
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2021
Matèries:
Preclinical Studies
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8280034/
https://ncbi.nlm.nih.gov/pubmed/33624234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-021-01087-5
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