A novel methylated analogue of L-Mimosine exerts its therapeutic potency through ROS production and ceramide-induced apoptosis in malignant melanoma

Melanoma is an aggressive and highly metastatic type of skin cancer where the design of new therapies is of utmost importance for the clinical management of the disease. Thus, we have aimed to investigate the mode of action by which a novel methylated analogue of L-Mimosine (e.g., L-SK-4) exerts its...

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Detalhes bibliográficos
Publicado no:Invest New Drugs
Main Authors: Kyriakou, Sotiris, Cheung, William, Mantso, Theodora, Mitsiogianni, Melina, Anestopoulos, Ioannis, Veuger, Stephany, Trafalis, Dimitris T., Franco, Rodrigo, Pappa, Aglaia, Tetard, David, Panayiotidis, Mihalis I.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2021
Assuntos:
Preclinical Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8280034/
https://ncbi.nlm.nih.gov/pubmed/33624234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-021-01087-5
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