Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells

Glioblastoma multiforme (GBM), the most aggressive brain cancer, recurs because glioblastoma stem cells (GSCs) are resistant to all standard therapies. We showed that GSCs, but not normal astrocytes, are sensitive to lysis by healthy allogeneic natural killer (NK) cells in vitro. Mass cytometry and...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Shaim, Hila, Shanley, Mayra, Basar, Rafet, Daher, May, Gumin, Joy, Zamler, Daniel B., Uprety, Nadima, Wang, Fang, Huang, Yuefan, Gabrusiewicz, Konrad, Miao, Qi, Dou, Jinzhuang, Alsuliman, Abdullah, Kerbauy, Lucila N., Acharya, Sunil, Mohanty, Vakul, Mendt, Mayela, Li, Sufang, Lu, JunJun, Wei, Jun, Fowlkes, Natalie W., Gokdemir, Elif, Ensley, Emily L., Kaplan, Mecit, Kassab, Cynthia, Li, Li, Ozcan, Gonca, Banerjee, Pinaki P., Shen, Yifei, Gilbert, April L., Jones, Corry M., Bdiwi, Mustafa, Nunez-Cortes, Ana K., Liu, Enli, Yu, Jun, Imahashi, Nobuhiko, Muniz-Feliciano, Luis, Li, Ye, Hu, Jian, Draetta, Giulio, Marin, David, Yu, Dihua, Mielke, Stephan, Eyrich, Matthias, Champlin, Richard E., Chen, Ken, Lang, Frederick F., Shpall, Elizabeth J., Heimberger, Amy B., Rezvani, Katayoun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8279586/
https://ncbi.nlm.nih.gov/pubmed/34138753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI142116
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