Extracellular GAPDH Promotes Alzheimer Disease Progression by Enhancing Amyloid-β Aggregation and Cytotoxicity

Neuronal cell death at late stages of Alzheimer’s disease (AD) causes the release of cytosolic proteins. One of the most abundant such proteins, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), forms stable aggregates with extracellular amyloid-β (Aβ). We detect these aggregates in cerebrospinal fl...

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Detalhes bibliográficos
Publicado no:Aging Dis
Main Authors: Lazarev, Vladimir F, Tsolaki, Magda, Mikhaylova, Elena R, Benken, Konstantin A, Shevtsov, Maxim A, Nikotina, Alina D, Lechpammer, Mirna, Mitkevich, Vladimir A, Makarov, Alexander A, Moskalev, Alexey A, Kozin, Sergey A, Margulis, Boris A, Guzhova, Irina V, Nudler, Evgeny
Formato: Artigo
Idioma:Inglês
Publicado em: JKL International LLC 2021
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Orginal Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8279520/
https://ncbi.nlm.nih.gov/pubmed/34341704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14336/AD.2020.1230
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