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Partial microglial depletion is associated with impaired hippocampal synaptic and cognitive function in young and aged rats
The role of microglia in mediating age-related changes in cognition and hippocampal synaptic function was examined by microglial depletion and replenishment using PLX3397. We observed age-related differences in microglial number and morphology, as well as increased Iba-1 expression, indicating micro...
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| Publicado no: | Glia |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8278544/ https://ncbi.nlm.nih.gov/pubmed/33586813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23975 |
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