DNA Methylation of Synaptic Genes in the Prefrontal Cortex Is Associated with Aging and Age-Related Cognitive Impairment

The current study investigates DNA methylation as a possible epigenetic regulator of transcription associated with aging and cognitive function. Young and aged male Fischer 344 rats were behaviorally characterized on a set shifting task, and whole genome bisulfite sequencing was employed to profile...

Full description

Saved in:
Bibliographic Details
Published in:Front Aging Neurosci
Main Authors: Ianov, Lara, Riva, Alberto, Kumar, Ashok, Foster, Thomas C.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539085/
https://ncbi.nlm.nih.gov/pubmed/28824413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2017.00249
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items