Genomic Heterogeneity and Copy Number Variant Burden are Associated with Poor Recurrence Free Survival and 11q Loss in HPV+ Squamous Cell Carcinoma of the Oropharynx

BACKGROUND: HPV positive squamous cell carcinoma of the oropharynx (OPSCC) is the most prevalent HPV associated malignancy in the United States. Favorable treatment outcomes have led to increasing interest in treatment de-escalation to reduce treatment morbidity; as well as developing prognostic mar...

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Udgivet i:Cancer
Main Authors: Schrank, Travis P., Lenze, Nicholas, Landess, Lee P., Hoyle, Alan, Parker, Joel, Lal, Asim, Sheth, Siddharth, Chera, Bhishamjit S., Patel, Samip N., Hackman, Trevor G., Major, M. Ben, Issaeva, Natalia, Yarbrough, Wendell G.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8277690/
https://ncbi.nlm.nih.gov/pubmed/33819343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.33504
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