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Sequences in the stalk domain regulate auto-inhibition and ciliary tip localization of the immotile kinesin-4 KIF7
The kinesin-4 member KIF7 plays critical roles in Hedgehog signaling in vertebrate cells. KIF7 is an atypical kinesin as it binds to microtubules but is immotile. We demonstrate that, like conventional kinesins, KIF7 is regulated by auto-inhibition, as the full-length protein is inactive for microtu...
Shranjeno v:
| izdano v: | J Cell Sci |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Company of Biologists Ltd
2021
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8277141/ https://ncbi.nlm.nih.gov/pubmed/34114033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.258464 |
| Oznake: |
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