Functionally Essential Tubular Proteins Are Lost to Urine-Excreted, Large Extracellular Vesicles during Chronic Renal Insufficiency

BACKGROUND: The 5/6 nephrectomy (5/6Nx) rat model recapitulates many elements of human CKD. Within weeks of surgery, 5/6Nx rats spontaneously exhibit proximal tubular damage, including the production of very large extracellular vesicles and brush border shedding. We hypothesized that production and...

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Detalhes bibliográficos
Publicado no:Kidney360
Main Authors: Adam, Ryan J., Paterson, Mark R., Wardecke, Lukus, Hoffmann, Brian R., Kriegel, Alison J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2020
Assuntos:
Original Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8276873/
https://ncbi.nlm.nih.gov/pubmed/34263177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.34067/KID.0001212020
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