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Targeting FAK in anti-cancer combination therapies
Focal adhesion kinase (FAK) is both a non-receptor tyrosine kinase and an adaptor protein that primarily regulates adhesion signalling and cell migration, but FAK can also promote cell survival in response to stress. FAK impacts on a diverse range of cancer cell functions mediated by both its kinase...
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| Veröffentlicht in: | Nat Rev Cancer |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8276817/ https://ncbi.nlm.nih.gov/pubmed/33731845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41568-021-00340-6 |
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