2dFDR: a new approach to confounder adjustment substantially increases detection power in omics association studies

One challenge facing omics association studies is the loss of statistical power when adjusting for confounders and multiple testing. The traditional statistical procedure involves fitting a confounder-adjusted regression model for each omics feature, followed by multiple testing correction. Here we...

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Detaylı Bibliyografya
Yayımlandı:Genome Biol
Asıl Yazarlar: Yi, Sangyoon, Zhang, Xianyang, Yang, Lu, Huang, Jinyan, Liu, Yuanhang, Wang, Chen, Schaid, Daniel J., Chen, Jun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2021
Konular:
Method
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8276451/
https://ncbi.nlm.nih.gov/pubmed/34256818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02418-8
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