2dFDR: a new approach to confounder adjustment substantially increases detection power in omics association studies

One challenge facing omics association studies is the loss of statistical power when adjusting for confounders and multiple testing. The traditional statistical procedure involves fitting a confounder-adjusted regression model for each omics feature, followed by multiple testing correction. Here we...

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Detalles Bibliográficos
Publicado en:Genome Biol
Autores principales: Yi, Sangyoon, Zhang, Xianyang, Yang, Lu, Huang, Jinyan, Liu, Yuanhang, Wang, Chen, Schaid, Daniel J., Chen, Jun
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2021
Materias:
Method
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8276451/
https://ncbi.nlm.nih.gov/pubmed/34256818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02418-8
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