A ciliopathy complex builds distal appendages to initiate ciliogenesis

Cells inherit two centrioles, the older of which is uniquely capable of generating a cilium. Using proteomics and superresolved imaging, we identify a module that we term DISCO (distal centriole complex). The DISCO components CEP90, MNR, and OFD1 underlie human ciliopathies. This complex localizes t...

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Detalles Bibliográficos
Publicado en:J Cell Biol
Autores principales: Kumar, Dhivya, Rains, Addison, Herranz-Pérez, Vicente, Lu, Quanlong, Shi, Xiaoyu, Swaney, Danielle L., Stevenson, Erica, Krogan, Nevan J., Huang, Bo, Westlake, Christopher, Garcia-Verdugo, Jose Manuel, Yoder, Bradley K., Reiter, Jeremy F.
Formato: Artigo
Lenguaje:Inglês
Publicado: Rockefeller University Press 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8276316/
https://ncbi.nlm.nih.gov/pubmed/34241634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202011133
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