BET inhibition increases βIII-tubulin expression and sensitizes metastatic breast cancer in the brain to vinorelbine

Metastases from primary breast cancer result in poor survival. βIII-tubulin (TUBB3) has been established as a therapeutic target for breast cancer metastases specifically to the brain. In this study, we conducted a systematic analysis to determine the regulation of TUBB3 expression in breast cancer...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Kanojia, Deepak, Panek, Wojciech K., Cordero, Alex, Fares, Jawad, Xiao, Annie, Savchuk, Solomiia, Kumar, Krishan, Xiao, Ting, Pituch, Katarzyna C., Miska, Jason, Zhang, Peng, Kam, Kwok-Ling, Horbinski, Craig, Balyasnikova, Irina V., Ahmed, Atique U., Lesniak, Maciej S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8276250/
https://ncbi.nlm.nih.gov/pubmed/32848091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax2879
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