A genome-first approach to mortality and metabolic phenotypes in MTARC1 p.Ala165Thr (rs2642438) heterozygotes and homozygotes

BACKGROUND: A coding variant in MTARC1 (rs2642438; p.Ala165Thr) was recently associated with protection from cirrhosis in European individuals. However, its impact on overall and cause-specific mortality remained elusive. METHODS: Using a genome-first approach, we explored a range of metabolic pheno...

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Vydáno v:Med (N Y)
Hlavní autoři: Schneider, Carolin V., Schneider, Kai Markus, Conlon, Donna M., Park, Joseph, Vujkovic, Marijana, Zandvakili, Inuk, Ko, Yi-An, Trautwein, Christian, Center, Regerneron, Carr, Rotonya M., Strnad, Pavel, Thaiss, Christoph A., Rader, Daniel J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274545/
https://ncbi.nlm.nih.gov/pubmed/34258604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.medj.2021.04.011
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