Leukocyte β-glucosidase in homozygotes and heterozygotes for Gaucher disease

Human leukocytes contain at least two isozymes of 4-methylumbelliferyl-β-glucosidase acting optimally at pH 4.0 and 4.8; in Gaucher disease, only the former is deficient. Brief exposure of the leukocyte homogenate to pH 4.0 at room temperature results in irreversible inactivation of the pH 4.8 activ...

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Bibliographic Details
Main Authors: Raghavan, S. S., Topol, J., Kolodny, E. H.
Format: Artigo
Language:Inglês
Published: 1980
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1686022/
https://ncbi.nlm.nih.gov/pubmed/6770675
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