Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205

[Image: see text] Synthetic endoperoxide antimalarials, such as 1,2,4-trioxolanes and 1,2,4,5-tetraoxanes, are promising successors for current front-line antimalarials, semisynthetic artemisinin derivatives. However, limited solubility of second-generation analogues in biological-relevant media rep...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Woodley, Christopher M., Nixon, Gemma L., Basilico, Nicoletta, Parapini, Silvia, Hong, Weiqian David, Ward, Stephen A., Biagini, Giancarlo A., Leung, Suet C., Taramelli, Donatella, Onuma, Keiko, Hasebe, Takashi, O’Neill, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274084/
https://ncbi.nlm.nih.gov/pubmed/34267877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00031
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