Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell

[Image: see text] Nicotinamide N-methyltransferase (NNMT), which catalyzes the methylation of nicotinamide, is a cytosolic enzyme that has attracted much attention as a therapeutic target for a variety of diseases. However, despite the considerable interest in this target, reports of NNMT inhibitors...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Med Chem Lett
Prif Awduron: Hayashi, Kyohei, Uehara, Shota, Yamamoto, Shiho, Cary, Douglas R., Nishikawa, Junichi, Ueda, Taichi, Ozasa, Hiroki, Mihara, Kousuke, Yoshimura, Norito, Kawai, Taeko, Ono, Takashi, Yamamoto, Saki, Fumoto, Masataka, Mikamiyama, Hidenori
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2021
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274071/
https://ncbi.nlm.nih.gov/pubmed/34267879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00134
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