NNMT activation can contribute to the development of fatty liver disease by modulating the NAD(+) metabolism

Nicotinamide N-methyltransferase (NNMT) catalyses the reaction between nicotinamide (NAM) and S-adenosylmethionine to produce 1-methylnicotinamide and S-adenosylhomocysteine. Recently, this enzyme has also been reported to modulate hepatic nutrient metabolism, but its role in the liver has not been...

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Publié dans:Sci Rep
Auteurs principaux: Komatsu, Motoaki, Kanda, Takeshi, Urai, Hidenori, Kurokochi, Arata, Kitahama, Rina, Shigaki, Shuhei, Ono, Takashi, Yukioka, Hideo, Hasegawa, Kazuhiro, Tokuyama, Hirobumi, Kawabe, Hiroshi, Wakino, Shu, Itoh, Hiroshi
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988709/
https://ncbi.nlm.nih.gov/pubmed/29872122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26882-8
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