PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice

Obesity-induced secretory disorder of adipose tissue–derived factors is important for cardiac damage. However, whether platelet-derived growth factor-D (PDGF-D), a newly identified adipokine, regulates cardiac remodeling in angiotensin II (AngII)–infused obese mice is unclear. Here, we found obesity...

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Publicado no:J Exp Med
Main Authors: Cheng, Yu-Wen, Zhang, Ze-Bei, Lan, Bei-Di, Lin, Jing-Rong, Chen, Xiao-Hui, Kong, Ling-Ran, Xu, Lian, Ruan, Cheng-Chao, Gao, Ping-Jin
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8273546/
https://ncbi.nlm.nih.gov/pubmed/34236404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20210252
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