Programmed PPAR-α downregulation induces inflammaging by suppressing fatty acid catabolism in monocytes

Inflammaging is associated with an increased risk of chronic disease. Monocytes are the principal immune cells for the production of inflammatory cytokines and contribute to inflammaging in the elderly. However, the underlying mechanisms remain largely unknown. Here, we found that monocytes from age...

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Udgivet i:iScience
Main Authors: Wang, Ming, Yan, Yan, Zhang, Zhengguo, Yao, Xiaohan, Duan, Xixi, Jiang, Ziming, An, Junfeng, Zheng, Peiguo, Han, Yijie, Wu, Hao, Wang, Zhaoqing, Glauben, Rainer, Qin, Zhihai
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8273418/
https://ncbi.nlm.nih.gov/pubmed/34286232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102766
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