Mutational Landscape of Pirin and Elucidation of the Impact of Most Detrimental Missense Variants That Accelerate the Breast Cancer Pathways: A Computational Modelling Study

Pirin (PIR) protein is highly conserved in both prokaryotic and eukaryotic organisms. Recently, it has been identified that PIR positively regulates breast cancer cell proliferation, xenograft tumor formation, and metastasis, through an enforced transition of G1/S phase of the cell cycle by upregula...

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Dettagli Bibliografici
Pubblicato in:Front Mol Biosci
Autori principali: Suleman, Muhammad, Tahir ul Qamar, Muhammad, Saleem, Shoaib, Ahmad, Sajjad, Ali, Syed Shujait, Khan, Haji, Akbar, Fazal, Khan, Wajid, Alblihy, Adel, Alrumaihi, Faris, Waseem, Muhammad, Allemailem, Khaled S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Molecular Biosciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8273169/
https://ncbi.nlm.nih.gov/pubmed/34262943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.692835
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