Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase

Mutations in the human peptide:N-glycanase gene (NGLY1), which encodes a cytosolic de–N-glycosylating enzyme, cause a congenital autosomal recessive disorder. In rodents, the loss of Ngly1 results in severe developmental delay or lethality, but the underlying mechanism remains unknown. In this study...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Yoshida, Yukiko, Asahina, Makoto, Murakami, Arisa, Kawawaki, Junko, Yoshida, Meari, Fujinawa, Reiko, Iwai, Kazuhiro, Tozawa, Ryuichi, Matsuda, Noriyuki, Tanaka, Keiji, Suzuki, Tadashi
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8271764/
https://ncbi.nlm.nih.gov/pubmed/34215698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2102902118
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