A mechanistic model captures the emergence and implications of non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cells

Resistance to anti-estrogen therapy is an unsolved clinical challenge in successfully treating ER+ breast cancer patients. Recent studies have demonstrated the role of non-genetic (i.e. phenotypic) adaptations in tolerating drug treatments; however, the mechanisms and dynamics of such non-genetic ad...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:NAR Cancer
Hauptverfasser: Sahoo, Sarthak, Mishra, Ashutosh, Kaur, Harsimran, Hari, Kishore, Muralidharan, Srinath, Mandal, Susmita, Jolly, Mohit Kumar
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
Schlagworte:
Cancer Computational Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8271219/
https://ncbi.nlm.nih.gov/pubmed/34316714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcab027
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