DNA G-Quadruplexes Contribute to CTCF Recruitment

G-quadruplex (G4) sites in the human genome frequently colocalize with CCCTC-binding factor (CTCF)-bound sites in CpG islands (CGIs). We aimed to clarify the role of G4s in CTCF positioning. Molecular modeling data suggested direct interactions, so we performed in vitro binding assays with quadruple...

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Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Tikhonova, Polina, Pavlova, Iulia, Isaakova, Ekaterina, Tsvetkov, Vladimir, Bogomazova, Alexandra, Vedekhina, Tatjana, Luzhin, Artem V., Sultanov, Rinat, Severov, Vjacheslav, Klimina, Ksenia, Kantidze, Omar L., Pozmogova, Galina, Lagarkova, Maria, Varizhuk, Anna
Format: Artigo
Langue:Inglês
Publié: MDPI 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8269367/
https://ncbi.nlm.nih.gov/pubmed/34209337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22137090
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