Possible Therapeutic Strategy Involving the Purine Synthesis Pathway Regulated by ITK in Tongue Squamous Cell Carcinoma

SIMPLE SUMMARY: We identified overexpression of interleukin-2–inducible T-cell kinase (ITK) as a novel biomarker for predicting the prognosis of tongue squamous cell carcinoma patients with poor outcomes. Oral cancer cell lines overexpressing ITK exhibited significantly increased proliferation in th...

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Publié dans:Cancers (Basel)
Auteurs principaux: Onidani, Kaoru, Miura, Nami, Sugiura, Yuki, Abe, Yuichi, Watabe, Yukio, Kakuya, Takanori, Mori, Taisuke, Yoshimoto, Seiichi, Adachi, Jun, Kiyoi, Takao, Kabe, Yasuaki, Suematsu, Makoto, Tomonaga, Takeshi, Shibahara, Takahiko, Honda, Kazufumi
Format: Artigo
Langue:Inglês
Publié: MDPI 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8269312/
https://ncbi.nlm.nih.gov/pubmed/34283052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13133333
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