Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance

The emergence of the plasmid-mediated high-level tigecycline resistance mechanism Tet(X) threatens the role of tigecycline as the “last-resort” antibiotic in the treatment of infections caused by carbapenem-resistant Gram-negative bacteria. Compared with that of the prototypical Tet(X), the enzymati...

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Udgivet i:mSystems
Main Authors: Cui, Chao-Yue, He, Qian, Jia, Qiu-Lin, Li, Cang, Chen, Chong, Wu, Xiao-Ting, Zhang, Xiao-Jing, Lin, Zhuo-Yu, Zheng, Zi-Jian, Liao, Xiao-Ping, Kreiswirth, Barry N., Liu, Ya-Hong, Chen, Liang, Sun, Jian
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8269203/
https://ncbi.nlm.nih.gov/pubmed/34006624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSystems.00050-21
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