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Cytosolic 5′-Nucleotidase II Silencing in Lung Tumor Cells Regulates Metabolism through Activation of the p53/AMPK Signaling Pathway

Cytosolic 5′-nucleotidase II (cN-II) is an allosteric catabolic enzyme that hydrolyzes IMP, GMP, and AMP. The enzyme can assume at least two different structures, being the more active conformation stabilized by ATP and the less active by inorganic phosphate. Therefore, the variation in ATP concentr...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Pesi, Rossana, Allegrini, Simone, Garcia-Gil, Mercedes, Piazza, Lucia, Moschini, Roberta, Jordheim, Lars Petter, Camici, Marcella, Tozzi, Maria Grazia
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8268954/
https://ncbi.nlm.nih.gov/pubmed/34209768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22137004
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