Cytosolic 5′-Nucleotidase II Silencing in Lung Tumor Cells Regulates Metabolism through Activation of the p53/AMPK Signaling Pathway

Cytosolic 5′-nucleotidase II (cN-II) is an allosteric catabolic enzyme that hydrolyzes IMP, GMP, and AMP. The enzyme can assume at least two different structures, being the more active conformation stabilized by ATP and the less active by inorganic phosphate. Therefore, the variation in ATP concentr...

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Publicado en:Int J Mol Sci
Main Authors: Pesi, Rossana, Allegrini, Simone, Garcia-Gil, Mercedes, Piazza, Lucia, Moschini, Roberta, Jordheim, Lars Petter, Camici, Marcella, Tozzi, Maria Grazia
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8268954/
https://ncbi.nlm.nih.gov/pubmed/34209768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22137004
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