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Cytosolic 5′-Nucleotidase II Silencing in a Human Lung Carcinoma Cell Line Opposes Cancer Phenotype with a Concomitant Increase in p53 Phosphorylation

Purine homeostasis is maintained by a purine cycle in which the regulated member is a cytosolic 5′-nucleotidase II (cN-II) hydrolyzing IMP and GMP. Its expression is particularly high in proliferating cells, indeed high cN-II activity or expression in hematological malignancy has been associated to...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Int J Mol Sci
Main Authors: Pesi, Rossana, Petrotto, Edoardo, Colombaioni, Laura, Allegrini, Simone, Garcia-Gil, Mercedes, Camici, Marcella, Jordheim, Lars Petter, Tozzi, Maria Grazia
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI 2018
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6073589/
https://ncbi.nlm.nih.gov/pubmed/30037008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19072115
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