High Glucose Exposure Impairs L-Cell Differentiation in Intestinal Organoids: Molecular Mechanisms and Clinical Implications

Intestinal organoids are used to analyze the differentiation of enteroendocrine cells (EECs) and to manipulate their density for treating type 2 diabetes. EEC differentiation is a continuous process tightly regulated in the gut by a complex regulatory network. However, the effect of chronic hypergly...

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Publicado en:Int J Mol Sci
Autores principales: Filippello, Agnese, Di Mauro, Stefania, Scamporrino, Alessandra, Malaguarnera, Roberta, Torrisi, Sebastiano Alfio, Leggio, Gian Marco, Di Pino, Antonino, Scicali, Roberto, Purrello, Francesco, Piro, Salvatore
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8268781/
https://ncbi.nlm.nih.gov/pubmed/34206340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22136660
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