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MK-6482 as a potential treatment for von Hippel-Lindau disease-associated clear cell renal cell carcinoma

INTRODUCTION: Von Hippel-Lindau (VHL) disease is an inherited autosomal dominant syndrome caused by a germline mutation and/or deletion of the VHL gene. Inappropriate hypoxia inducible factor (HIF) meditated transcription of proangiogenic and metabolic genes leads to the development of tumors and cy...

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Detalhes bibliográficos
Publicado no:Expert Opin Investig Drugs
Main Authors: Hasanov, Elshad, Jonasch, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8268068/
https://ncbi.nlm.nih.gov/pubmed/33945366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/13543784.2021.1925248
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