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MK-6482 as a potential treatment for von Hippel-Lindau disease-associated clear cell renal cell carcinoma
INTRODUCTION: Von Hippel-Lindau (VHL) disease is an inherited autosomal dominant syndrome caused by a germline mutation and/or deletion of the VHL gene. Inappropriate hypoxia inducible factor (HIF) meditated transcription of proangiogenic and metabolic genes leads to the development of tumors and cy...
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| Izdano u: | Expert Opin Investig Drugs |
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| Glavni autori: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2021
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8268068/ https://ncbi.nlm.nih.gov/pubmed/33945366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/13543784.2021.1925248 |
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