Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators

[Image: see text] Small-molecular Toll-like receptor 7/8 (TLR7/8) agonists hold promise as immune modulators for a variety of immune therapeutic purposes including cancer therapy or vaccination. However, due to their rapid systemic distribution causing difficult-to-control inflammatory off-target ef...

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Publicado en:J Am Chem Soc
Main Authors: Huppertsberg, Anne, Kaps, Leonard, Zhong, Zifu, Schmitt, Sascha, Stickdorn, Judith, Deswarte, Kim, Combes, Francis, Czysch, Christian, De Vrieze, Jana, Kasmi, Sabah, Choteschovsky, Niklas, Klefenz, Adrian, Medina-Montano, Carolina, Winterwerber, Pia, Chen, Chaojian, Bros, Matthias, Lienenklaus, Stefan, Sanders, Niek N., Koynov, Kaloian, Schuppan, Detlef, Lambrecht, Bart N., David, Sunil A., De Geest, Bruno G., Nuhn, Lutz
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2021
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8267846/
https://ncbi.nlm.nih.gov/pubmed/34166595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.1c03772
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