Clinical and Molecular Heterogeneity in Patients with Innate Resistance to Anti-PD-1 +/− Anti-CTLA-4 Immunotherapy in Metastatic Melanoma Reveals Distinct Therapeutic Targets

SIMPLE SUMMARY: Immune checkpoint therapies have significantly improved the survival of patients with metastatic melanoma, however approximately 50% of patients exhibit no response. Understanding the underlying clinical, pathologic and genetic factors associated with failed response to immunotherapi...

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Udgivet i:Cancers (Basel)
Main Authors: Gide, Tuba N., Pires da Silva, Inês, Quek, Camelia, Ferguson, Peter M., Batten, Marcel, Shang, Ping, Ahmed, Tasnia, Menzies, Alexander M., Carlino, Matteo S., Saw, Robyn P. M., Thompson, John F., Scolyer, Richard A., Long, Georgina V., Wilmott, James S.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8267740/
https://ncbi.nlm.nih.gov/pubmed/34202352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13133186
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