Overexpression of miR-125b in Osteoblasts Improves Age-Related Changes in Bone Mass and Quality through Suppression of Osteoclast Formation

We recently reported an unexpected role of osteoblast-derived matrix vesicles in the delivery of microRNAs to bone matrix. Of such microRNAs, we found that miR-125b inhibited osteoclast formation by targeting Prdm1 encoding a transcriptional repressor of anti-osteoclastogenesis factors. Transgenic (...

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Bibliografiska uppgifter
I publikationen:Int J Mol Sci
Huvudupphovsmän: Ito, Shota, Minamizaki, Tomoko, Kohno, Shohei, Sotomaru, Yusuke, Kitaura, Yoshiaki, Ohba, Shinsuke, Sugiyama, Toshie, Aubin, Jane E., Tanimoto, Kotaro, Yoshiko, Yuji
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2021
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8267655/
https://ncbi.nlm.nih.gov/pubmed/34201781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22136745
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