Human GPR17 missense variants identified in metabolic disease patients have distinct downstream signaling profiles

GPR17 is a G-protein-coupled receptor (GPCR) implicated in the regulation of glucose metabolism and energy homeostasis. Such evidence is primarily drawn from mouse knockout studies and suggests GPR17 as a potential novel therapeutic target for the treatment of metabolic diseases. However, links betw...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Conley, Jason M., Sun, Hongmao, Ayers, Kristin L., Zhu, Hu, Chen, Rong, Shen, Min, Hall, Matthew D., Ren, Hongxia
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2021
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8267566/
https://ncbi.nlm.nih.gov/pubmed/34144038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100881
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